This topic addresses the growing interest of science and industry in the synthesis, characterization, testing, and application of biomaterials, as well as their closely related areas of medical devices, drug delivery, and tissue engineering. The motivation is not only the recent scientific progress in biomedical materials but also challenges on this exciting and strongly interdisciplinary field of science and engineering.
Materials scientists, physicists, chemists, and biologists in industrial R&D, as well as medical professionals are increasingly facing situations where materials are confronted with high performance requirements and a challenging biological environment at the same time.
Mimicking the extracellular matrix is a promising strategy to gain control over cellular behavior. Therefore hydrogels are an important class of biomaterials. Their water-binding capacity makes them ideal synthetic matrices. As “material and form follow function”, hydrogels can be made of natural as well as synthetic polymers and in almost any shape, depending on the task they need to fulfill. Due to this versatility including their vast diverse chemical properties, hydrogels are widely used in biomaterials science and cell biology to study effects of mechanical properties, surface topology, 3D architecture, biofunctionalization and growth factor binding on biological systems. Furthermore, they are promising tools in tissue engineering due to their tunable physical and chemical properties. This symposium aims to bring together researchers from different fields who develop bio-instructive platforms using hydrogels. Light will be shed on the different types of hydrogels, on processing strategies such as additive manufacturing, and on their potential in fundamental research as well as on clinical translational and biotechnological applications.
Cornelia Lee-Thedieck - Karlsruhe Institute of Technology, Institute of Functional Interfaces, Germany
Christine Selhuber-Unkel - Kiel University, Institute for Materials Science, Germany
Patrick van Rijn - University of Groningen, Faculty of Medical Sciences, The Netherlands
Temporary implant materials based on biodegradable metals are breaking the current paradigm in biomaterial science to develop only corrosion resistant metals. Especially metals and alloys which are mainly made of physiological trace elements are promising candidates for this approach. The idea of biodegradable implants and coatings is to support tissue regeneration and tissue healing in a specific application by material degradation and concurrent implant replacement through the surrounding tissue. To get an overview over the current experimental and clinical applications this symposium is open for all kinds of degradable materials such as polymers, ceramics or bioactive glasses. It is intended to discuss the degradation mechanisms, cellular reactions and the design of in vitro tests for this class of materials.
Daniela Zander - RWTH Aachen University, Corrosion and Corrosion Protection, Germany
Frank Feyerabend - Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Germany
Bert Müller - University of Basel, Medical Faculty, Switzerland
Nature successfully employs inorganic solid-state materials (i.e., biominerals) into hierarchical composites as sensing elements, weapons, tools, or as shelters. Optimized over hundreds of millions of years under evolutionary pressures, these composites are exceptionally adopted to a set of specifications for which and under which they function. Made from mundane materials templated by scaffolds under ambient conditions, the exquisite hierarchical organization of these biominerals often enables multifunctionality. These bioconstructs thus serve as a library of brilliant engineering solutions where the interplay between components is critical to nano- to the macrostructure hierarchical control. This symposium will address recent advancements in our understanding of the synthesis and properties of biogenic ceramic materials, along with current developments in our venture to transform our newly gained insights into novel approaches for materials design and synthesis. Representative topics include: self-organization, (non)classical crystallization, structure-property relationships of structured, graded or composite materials.
Stephan E. Wolf - Friedrich-Alexander Universität Erlangen-Nürnberg, Institute of Glass and Ceramics, Germany
Fabio Nudelman - The University of Edinburgh, School of Chemistry, Great Britain
David Kisailus - University of California at Riverside, Department of Chemical and Environmental Engineering, Materials Science & Engineering, USA
This symposium will attract experts working in the broad field of biomedical applications of materials, including metals, ceramics, polymers and their composites. Presentations will include topics ranging from biomedical implants, coatings and surface treatment of biomaterials to novel biomaterial approaches for tissue engineering, regenerative medicine and drug delivery. Thus biomedical applications of both permanent and biodegradable materials will be considered in this symposium. Moreover advanced methods for the characterization and testing of biomaterials in in-vivo relevant conditions will be also considered, with emphasis in the tissue/biomaterial interface. Other topics will include innovative multifunctional bioactive coatings for biomedical devices, as well as tailored surface functionalization approaches for eliciting specific biological responses. Biomaterial based approaches to develop advanced scaffolds for tissue regeneration will be also covered in this symposium. New concepts directed at the development of multifunctional scaffolds (next generation scaffolds) will be presented, which can have a drug delivery or biomolecular signalling function thus providing enhanced support to cell attachment, growth and proliferation. The symposium will offer an excellent forum to present and discuss the most recent and relevant contributions to application of materials in the biomedical field, bringing together material scientists, biologists, pharmacists, tissue engineers and medical doctors.
Suggested topics are:
1. Bioactive materials as dense and porous implants
2. Functionally-graded biomaterials
3. Surface treatments and functionalization of bioactive materials
4. Scaffolds for tissue engineering
5. Tissue/Biomaterial Interface phenomena
6. Biodegradable medical devices
7. Clinical applications
8. Materials for controlled drug delivery
9. Bioactive, antibacterial coatings
Aldo R. Boccaccini - Friedrich-Alexander Universität Erlangen-Nürnberg, Department of Materials Science and Engineering, Germany
Viviana Mourino - University of Buenos Aires, Pharmaceutical Technology, Argentina
Jonny Blaker - University of Manchester, School of Materials, Great Britain
It is the mission of this interdisciplinary symposium to address recent advances in the development and examination of new bone substitute materials and implant materials for systemically altered bones. In the centre of attention are two diseases, whereby each of them results in a significantly heightened risk of bone fracture. Osteoporosis, which is a widespread bone degeneration disease predominantly occurring with old age, and also multiple myeloma, a malignant tumour disease, which results in localised destruction of bone tissue. Modern trauma surgery and orthopaedics can indeed avail of a variety of bone substitute materials and also of durable implants. However, those are not attuned to the specific conditions of systemic symptoms, which lead to a significant worsening of bone fracture healing and bone defect healing. The symposium will offer an excellent forum to present and discuss innovative solutions for such forms of bone defects and biomaterials.
Thomas Hanke - Technische Universität Dresden, Max Bergmann Center of Biomaterials, Germany
Christian Heiß - Universitätsklinikum Giessen, Germany
Anna Tampieri - National Research Council of Italy, Institue of Science and Technology for Ceramics, Italy
The longevity of prosthetic devices is strictly related to their ability of fast and direct bonding to the surrounding tissues. At the same time, the implant surfaces are often affected by bacteria adhesion, proliferation and development of biofilms, that can lead to peri-prosthetic infections, resistance to systemic antibiotic therapy and septic implant failure. This symposium is focused on the most recent topics concerning advanced compositions, new surface treatments and functionalization of materials for implantable devices, with enhanced tissue healing ability and antibacterial properties, in the field of both soft and hard tissue surgery and regeneration. Particular emphasis will be given to innovative processing technologies and to the investigation of the interface phenomena involved in the biological response.
In the frame of the above mentioned scenario, suggested topics are:
1. Innovative dense, porous, composite, bioactive materials and coatings;
2. Surface chemical treatments;
3. Surface functionalization;
4. Nanostructured surfaces;
5. Clinical applications.
Enrica Verne - Polytechnic of Turin, Department of Applied Science and Technology, Italy
Klaus D. Jandt - Friedrich Schiller University Jena, Chair of Materials Science, Germany
In the final programme, Symposium B07 will be part of Symposium B05.