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Keynote Lecture

WEB Dressing nanoparticles in cell’s clothing: The new generation of nanomedicines for biomedical applications

Tuesday (22.09.2020)
14:30 - 15:00 B: Biomaterials
Part of:

The recent cutting-edge advances on nanomaterials is anticipated to overcome some of the therapeutic window and clinical applicability of many drug/peptide molecules and can also act as innovative theranostic platform and tool for the clinic in the future. In this work, prominent nanosystems, such as biohybrid nanocomposites made of different nanoparticles and cell-based membrane materials are presented and discussed as potential platforms for the individualization of medical intervention. These nanotheranostic-based nano-biohybrids are promising advanced drug delivery technologies for different biomedical applications. Examples on how these biohybrid can be prepared and scaled-up, as well as how they can be used to enhance the drug’s targetability, intracellular drug delivery for cancer and heart diseases applications, will also be presented and discussed.

Yong et al., “Tumor Exosome-Based Nanoparticles are Efficient Drug Carriers for Chemotherapy”, Nature Commun. 2019, 10(1), 3838.

Zhang et al., “Photothermal Responsive Nanosized Hybrid Polymersome as Versatile Therapeutics Co-Delivery Nanovehicle for Effective Tumor Suppression”, Proc. Natl. Acad. Sci. U.S.A. 2019, 116(16) 7744–7749.

Fontana et al., “Biohybrid Vaccines for Improved Treatment of Aggressive Melanoma with Checkpoint Inhibitor”, ACS Nano 2019, 13(6), 6477–6490.

Liu et al., “Close-loop Dynamic Nanohybrids on Collagen-Ark with In-situ Gelling Transformation Capability for Bio-mimetically Stage Specific Diabetic Wound Healing”, Mater. Horiz. 2019, 6, 385–393.

Ferreira et al., “Dual-Drug Delivery Using Dextran-Functionalized Nanoparticles Targeting Cardiac Fibroblasts for Cellular Reprogramming”, Adv. Funct. Mater. 2018, 28(15), 1705134.

Liu et al., “Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics”, Adv. Mater. 2018, 30(24), 1703393.

Fontana et al., “Multistaged Nanovaccines based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy”, Adv. Mater. 2017, 29(7), 1603239.

Ferreira et al., Anu J. Airaksinen*, Hélder A. Santos*, “Drug-loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling”, Small 2017, 13(33), 1701276.

Prof. Hélder Santos
University of Helsinki