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Keynote Lecture

WEB Biomimetic and bioactive coatings: from fundamental understanding to pre-clinical applications

Wednesday (01.01.2020)
00:00 - 00:30
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In vivo, cells are surrounding by an extra-cellular matrix (ECM) which provide them with bioactive signals coming for the ECM proteins and growth factors. Presenting active biomolecules to cells in a spatially controlled manner to cells using biomaterials as carriers enable to mimic some aspects of the native ECM and to study cell signaling and tissue formation. Surface coatings made of biopolymers [1] can be engineered to trap the bone morphogenetic proteins and present the BMPs to cells at their ventral side. This matrix-bound presentation of growth factor to cells via a thin biomaterials enables to reveal so far hidden phenomena [2] [3]. This will be highlighted for bone morphogenetic proteins (BMPs) that induce bone tissue formation [2-4]. The spatial presentation of growth factors can be controlled at the cellular [5] and tissular scales [4]. These surface coatings can also be used in vivo for the regeneration and bone defects [6]. In addition, recent developments using a liquid handling robot enables to use them for high throughput screening of cellular behaviors [7] in view of fundamental studies and cell therapies.


References

[1] Gribova V, et al Chem Mater. 2012;24:854-69.

[2] Fourel L, et al . J Cell Biol. 2016;212:693-706.

[3] Gilde F, et al . Acta Biomater. 2016;46:55-67.

[4] Almodovar J, et al Biomaterials. 2014:3975-85.

[5] Fitzpatrick V et al Scientifc reports. 2017;7:41479.

[6] Bouyer M, et al. Biomaterials. 2016;104:168-81.

[7] Machillot P, et al Adv Mater. 2018;e1801097.


 

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