WEB Personalised, multifunctional coatings for medical devices against infections and adverse immune reactions
The personalized medicine approach has already paid dividends in patient-specific chemotherapy and other pharmaceutical applications. In the case of medical devices, the personalization is mainly based on the anatomical fit of the implants. However, the personalization of the implant interface to control better the host response to the implanted materials and also to diminish the risks such as infection is only recently come to be considered. Another important aspect is the ability to resolve several problems using only one coating. In this context, we have been developing multi-component coatings based on supramolecular assemblies where each component brings in an inherent biological activity while contributing to the physicochemical properties of the coating. As such assemblies can be produced by iterative processes, the coatings can be modified with respect to the patients' immunoprofiles. In this talk, a personalized coating development workflow including immunoprofiling and coating optimization using polypeptides and polysaccharides will be presented.