WEB Optimization of magnetite nanoparticles synthesis for their use in bioseparation studiesWednesday (23.09.2020) 13:01 - 13:02 Poster Room Part of:
In recent years nanoparticles have received increasing interest for medicinal applications, given their large surface-area-to-volume ratio which enables the surface decoration with versatile biomolecules including oligonucleotides, peptides, drugs and hormones. Magnetite is one very promising material, owing to its superparamagnetic properties, and has been employed for drug delivery, hyperthermia and magnetic separation experiments. Especially the latter represents a valuable tool for the selective extraction and detection of biomolecules from body fluids and is thus of great value for early-disease diagnosis. Here, we optimized the synthesis of magnetic iron oxide (γ-Fe2O3, Fe3O4) nanoparticles towards homogenous size distribution, colloidal stability, sufficient magnetic susceptibility and desired surface functionality that allow for the fast and selective separation of biomolecules from biological fluids. A focus was set towards the extraction of microRNAs which represent prognostic indicators for a variety of diseases including various cancer types.