WEB Tailored synthesis of iron oxide nanocrystals with controlled size, morphology and surface modification for bioimaging and -separationWednesday (01.01.2020) 02:45 - 03:00 Part of:
Out of a vast variety of metal and metal oxide nanoparticles that have been developed for medicinal purposes, iron oxides are one of a few materials that made it through clinical trials. Due to their high biocompatibility, stability and the abundance of iron in our environment, which results in low costs of iron-based materials, diverse iron oxide nanoparticles (IONPs) have been prepared. Especially the magnetic properties of maghemite and magnetite nanoparticles have aroused great interest as imaging agents for MRI and for magnetic targeting and separation processes.
Herein, the employment of specific surface ligands as well as controlled variation of reaction parameters during thermal decompositions, coprecipitations and solvothermal reactions enabled the synthesis of IONPs with highly homogeneous particle morphology (spherical, cube , ellipsoid-shaped), size (5-200 nm) and phase (Fe3O4, Fe1-xO, α-Fe2O3). Besides the synthesis of MRI contrast agents that could be used for ex-vivo imaging of novel brain implants, the selective attachment of microRNAs allowed for their use in bioseparation studies that revealed new insights into liver cancer development.