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WEB Surface-enhanced Raman scattering for disease diagnosis and/or screening

Wednesday (01.01.2020)
00:30 - 00:45
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Surface-enhanced Raman spectroscopy (SERS) has been extensively used for the detection and evaluation of biological substances in body fluids, such as blood, tissues and cells, due to the high sensitivity, specificity, efficiency and cost-effectiveness, with which urine, serum and saliva can be used for non-invasive disease diagnosis. A number of cancers, diseases and illicit drugs have been successfully recognized and analyzed based on SERS spectra of urine, serum and saliva, enabling screening of certain diseases and tracing of disease development. Here we show several examples of our efforts on improving the sensitivity, the thermal stability, the chemical stability and other performance of the Ag-based nanorods as the substrates for SERS, and the detection of human serum for the screening and staging of lung adenocarcinoma by SERS and statistical multivariate analysis. It was found that Raman spectra of the normal individuals and patients were discussed based on orthogonal partial least square discriminant analysis. The results showed that the specificity and sensitivity are pretty high, indicating a good classification of the two groups. In addition, with SERS and the analysis, one might also identify the stage of the patients with a fairly good overall screening accuracy. This study demonstrated that it could be developed into a plausible tool for the diagnosis or screening of specific diseases based on the SERS spectra of serum combined with plausible statistical analysis methods.

Prof. Zhenjun Zhang
Tsinghua University
Additional Authors:
  • Dr. Lingwei Ma
    Beijing science and technology University