Symposium

B08: Nanomaterials for Medicinal Applications

Belongs to:
TopicB: Biomaterials

The ongoing engineering of materials at the nanoscale has led to the development of innovative diagnostic and therapeutic agents that have the potential to revolutionize the conventional detection of various diseases at early stages and their treatment with reduced side-effects and high efficiencies. Precise control over nanomaterial size, morphology and composition allows for fine-tuning of their physicochemical properties for very specific applications followed by their surface modification with biocompatible linkers, evaluation on their up-scaling potential as well as their long-term stability in physiological milieu. Moreover, the fabrication of multimodal vectors that integrate more than one functional imaging or therapeutic unit offers the unique opportunity to obtain anatomical information with high sensitivity and resolution whilst allowing for e.g. triggered release of a specific drug. Especially the attachment of cell-specific biomolecules that differentiate between healthy and malignant cells has found increasing popularity to guide the theranostic agents to the place of interest and thereby reduce the systemic toxicity. However, profound evaluations of nanomaterial interactions with our immune system, which represents the first line of defense, are necessary to circumvent unwanted side-effects and comprehensive in vitro as well as ex vivo and in vivo studies are needed to gain a better understanding on their bioavailability, cellular accumulation and clearance.

The symposium thus aims to highlight the recent advances that have been made in the field of nanomedicine but will also critically evaluate current challenges on the way to clinical trials and the medicinal approval of novel nano-scaled agents. Topics will include:

  • Synthesis and characterization of nanomaterials
  • Surface conjugation strategies
  • Development of novel imaging agents
  • Drug delivery vehicles and other therapeutic applications
  • Nanotoxicity and immunological responses towards nanomaterials
  • Nanomaterial-based biosensors
  • Antibacterial and antifouling applications
  • Tissue engineering
  • in vitro, ex vivo and in vivo investigations
     

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